Description

This is a locally aggressive gingival squamous cell carcinoma in a 629 day old WSB/EiJ female mouse. It is in the site of the base of the molars that are inflammed due to impaction with food and hair that result in ulceration of the gingiva. Note the islands of squamous cells infiltrating into the alveolus of the bone. There are numerous mitotic figures and epithelial (keratin) pearl formations characteristic of squamous cell carcinomas.

MPATH / Pathology

MPATH 446 - squamous cell carcinoma

Gene

sex

Female

strain

WSB/EiJ

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99999 - Senescent

genotype status

Wild-type

genetic manipulation

None

MA / Anatomical Site

MA 342 - gingiva

Designated Allele Name

Experimental Manipulation

Further info

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Copyright

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Mouse Phenome Database

MPD number: 2007