Pathbase

Pathbase: PB 24133

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Pathbase Image PB 24133 submitted by University of Bath on 2003-11-07
Sex:Unknown
Gene:Trp53
Igf2
Strain:CBA:C57BL/6
Organism:Mouse
EMAP / Embryonic stage,
tissue or post-natal age:
Genotype Status:Hemizygous
Heterozygous
MPATH / Pathology:MPATH 55 - developmental and structural abnormality
MPATH 76 - heterotopia
Genetic Manipulation:Gene-knockout-deletion
Transgenic-Ectopic-overexpression
MA / Anatomical Site:MA 1527 - hindgut
Designated Allele Name:
Experimental Manipulation:
Description:Ectopic crypts in a P53 knockout mouse expressing Igf2 from a cytokeratin promoter


Magnification:x25
Stain:H&E


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0045182 - translation regulator activity
Search AmiGO:GO ID: 0001501 - skeletal development
Search AmiGO:GO ID: 0003677 - DNA binding
Search AmiGO:GO ID: 0003700 - transcription factor activity
Search AmiGO:GO ID: 0005159 - insulin-like growth factor receptor binding
Search AmiGO:GO ID: 0005515 - protein binding
Search AmiGO:GO ID: 0005615 - extracellular space
Search AmiGO:GO ID: 0005634 - nucleus
Search AmiGO:GO ID: 0005737 - cytoplasm
Search AmiGO:GO ID: 0005829 - cytosol
Search AmiGO:GO ID: 0030330 - DNA damage response, signal transduction by p53 class mediator
Search AmiGO:GO ID: 0000060 - protein-nucleus import, translocation
Search AmiGO:GO ID: 0006350 - transcription
Search AmiGO:GO ID: 0006915 - apoptosis
Search AmiGO:GO ID: 0007150 - growth pattern
Search AmiGO:GO ID: 0007275 - development
Search AmiGO:GO ID: 0008151 - cell growth and/or maintenance
Search AmiGO:GO ID: 0008286 - insulin receptor signaling pathway
Search AmiGO:GO ID: 0009887 - organogenesis
Search AmiGO:GO ID: 0009887 - organogenesis
Search AmiGO:GO ID: 0006349 - imprinting (Gene: Igf2)
Search AmiGO:GO ID: 0006355 - regulation of transcription, DNA-dependent (Gene: Trp53)
Search MGI@Jax:Gene: Igf2
Search MGI@Jax:Gene: Trp53
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!


Copyright
This image remains the property of the originating Institution and should not be modified, reproduced or disseminated without the express permission of the submitter.




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