PB 24133
Description
Ectopic crypts in a P53 knockout mouse expressing Igf2 from a cytokeratin promoter
MPATH / Pathology
MPATH 55 - developmental and structural abnormality
MPATH 76 - heterotopia
Gene
Trp53
Igf2
sex
Unknown
strain
CBA:C57BL/6
organism
Mouse
EMAP / Embryonic stage, tissue or post-natal age:
genotype status
Hemizygous
Heterozygous
genetic manipulation
Gene-knockout-deletion
Transgenic-Ectopic-overexpression
MA / Anatomical Site
MA 1527 - hindgut
Designated Allele Name
Experimental Manipulation
Further info
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Copyright
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Gene Ontology
GO ID: 0045182 - translation regulator activity GO ID: 0001501 - skeletal development GO ID: 0003677 - DNA binding GO ID: 0003700 - transcription factor activity GO ID: 0005159 - insulin-like growth factor receptor binding GO ID: 0005515 - protein binding GO ID: 0005615 - extracellular space GO ID: 0005634 - nucleus GO ID: 0005737 - cytoplasm GO ID: 0005829 - cytosol GO ID: 0030330 - DNA damage response, signal transduction by p53 class mediator GO ID: 0000060 - protein-nucleus import, translocation GO ID: 0006350 - transcription GO ID: 0006915 - apoptosis GO ID: 0007150 - growth pattern GO ID: 0007275 - development GO ID: 0008151 - cell growth and/or maintenance GO ID: 0008286 - insulin receptor signaling pathway GO ID: 0009887 - organogenesis GO ID: 0009887 - organogenesis GO ID: 0006349 - imprinting (Gene: Igf2)GO ID: 0006355 - regulation of transcription, DNA-dependent (Gene: Trp53)