|Pathbase Image PB 24082 submitted by University of Cambridge on 2003-11-01|
|EMAP / Embryonic stage, |
tissue or post-natal age:
|Genotype Status:||Wild-type |
|MPATH / Pathology:||MPATH 458 - normal|
|Genetic Manipulation:||None |
|MA / Anatomical Site:||MA 1602 - lower jaw molar|
|Designated Allele Name:|
|Description:||Late stage development of the first molar root. Root formation is still actively ongoing with deposition of dentine matrix within the pre-dentine zone (pre-dentine appears pale in comparison to the mineralised dentine) In the most apical region close to Hertwig`s root sheath, differentiation of odontoblasts is evident due to the transition from low cuboidal to cylidrical cell morphology with apically placed nuclei. Odontoblast differentiation occurs from ectomesenchymal neural crest derived precursor cells.|
The pulpal cavity is richly vascularised and composed of immature fibroblast-like cells situated in a very loose connective tissue matrix.
The root surface borders on an immature periodontal ligament composed of irregularly organised fibroblasts within a richly vascularised collagenous meshwork. In the upper left part of the image immature alveolar bone is present in which the bony trabeculae are lined by active osteoblasts.
In the lower left part of the picture the mandibular canal and the mandibular nerve can be seen.
|NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!
|This image remains the property of the originating Institution and should not be modified, reproduced or disseminated without the express permission of the submitter.