Pathbase: PB 24082


Pathbase Image PB 24082 submitted by University of Cambridge on 2003-11-01
Strain:C57BL/6 CRL
EMAP / Embryonic stage,
tissue or post-natal age:
Genotype Status:Wild-type
MPATH / Pathology:MPATH 458 - normal
Genetic Manipulation:None
MA / Anatomical Site:MA 1602 - lower jaw molar
Designated Allele Name:
Experimental Manipulation:
Description:Late stage development of the first molar root. Root formation is still actively ongoing with deposition of dentine matrix within the pre-dentine zone (pre-dentine appears pale in comparison to the mineralised dentine) In the most apical region close to Hertwig`s root sheath, differentiation of odontoblasts is evident due to the transition from low cuboidal to cylidrical cell morphology with apically placed nuclei. Odontoblast differentiation occurs from ectomesenchymal neural crest derived precursor cells.
The pulpal cavity is richly vascularised and composed of immature fibroblast-like cells situated in a very loose connective tissue matrix.
The root surface borders on an immature periodontal ligament composed of irregularly organised fibroblasts within a richly vascularised collagenous meshwork. In the upper left part of the image immature alveolar bone is present in which the bony trabeculae are lined by active osteoblasts.
In the lower left part of the picture the mandibular canal and the mandibular nerve can be seen.


Further Information
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