Pathbase: PB 2266


Pathbase Image PB 2266 submitted by helmholtz center munich, inst f radiation biology on 2002-10-17
Strain:(C3H/He El x 102/El F1) x T stock FI
EMAP / Embryonic stage,
tissue or post-natal age:
99998 - Adult
Genotype Status:Wild-type
MPATH / Pathology:MPATH 397 - osteosarcoma
Genetic Manipulation:None
MA / Anatomical Site:MA 1359 - femur
Designated Allele Name:
Experimental Manipulation:Radiation
Description:Osteosarcoma induced in T-stock x (C3H/He El x 102) F1 test crossed mice following injection with Thorium 227. T stock is an outbred line with 7 selected homozygote loci. See Russel et. al. (1996) Proc Natl. Acad Sci. 93, 13072-13077.
The tumour appeared in the distal part of the femur and shows formation of neoplastic
osteoid that resembles trabecular structures.
Atypical osteoblasts with pleomorphic nuclei
are also present.


Further Information
Search PubMed:PubMed number: 11893245
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