Description

Osteosarcoma induced in T-stock x (C3H/He El x 102) F1 test crossed mice following injection with Thorium 227. T stock is an outbred line with 7 selected homozygote loci. See Russel et. al. (1996) Proc Natl. Acad Sci. 93, 13072-13077.
The tumour appeared in the distal part of the femur and shows formation of neoplastic
osteoid that resembles trabecular structures.
Atypical osteoblasts with pleomorphic nuclei
are also present.

MPATH / Pathology

MPATH 397 - osteosarcoma

Gene

sex

Female

strain

(C3H/He El x 102/El F1) x T stock FI

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99998 - Adult

genotype status

Wild-type

genetic manipulation

None

MA / Anatomical Site

MA 1359 - femur

Designated Allele Name

Experimental Manipulation

Radiation

Further info

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Search PubMed:

PubMed number: 11893245