|Pathbase Image PB 2266 submitted by helmholtz center munich, inst f radiation biology on 2002-10-17|
|Strain:||(C3H/He El x 102/El F1) x T stock FI|
|EMAP / Embryonic stage, |
tissue or post-natal age:
|99998 - Adult|
|Genotype Status:||Wild-type |
|MPATH / Pathology:||MPATH 397 - osteosarcoma|
|Genetic Manipulation:||None |
|MA / Anatomical Site:||MA 1359 - femur|
|Designated Allele Name:|
|Experimental Manipulation:||Radiation |
|Description:||Osteosarcoma induced in T-stock x (C3H/He El x 102) F1 test crossed mice following injection with Thorium 227. T stock is an outbred line with 7 selected homozygote loci. See Russel et. al. (1996) Proc Natl. Acad Sci. 93, 13072-13077.|
The tumour appeared in the distal part of the femur and shows formation of neoplastic
osteoid that resembles trabecular structures.
Atypical osteoblasts with pleomorphic nuclei
are also present.
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