|Pathbase Image PB 2265 submitted by helmholtz center munich, inst f radiation biology on 2002-10-17|
|EMAP / Embryonic stage, |
tissue or post-natal age:
|99998 - Adult|
|Genotype Status:||Wild-type |
|MPATH / Pathology:||MPATH 397 - osteosarcoma|
|Genetic Manipulation:||None |
|MA / Anatomical Site:||MA 312 - lumbar vertebra|
|Designated Allele Name:|
|Experimental Manipulation:||Radiation |
|Description:||Osteosarcoma induced by Thorium 227 injection|
in congenic C3H/He mice, carrying a susceptibility allele from the 102-strain on chromosome 14.
The tumour originates from the medullary or trabecular structures
of the lumbar vertebrae and extends into the vertrebral canal.
Compression of the vertebral cord resulted in clinically obvious
paralysis of the hind legs.
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