Description

Osteosarcoma induced by Thorium ²²⁷ injection
in congenic C3H/He mice, carrying a susceptibility allele from the 102-strain on chromosome 14.
The tumour originates from the medullary or trabecular structures
of the lumbar vertebrae and extends into the vertrebral canal.
Compression of the vertebral cord resulted in clinically obvious
paralysis of the hind legs.

MPATH / Pathology

MPATH 397 - osteosarcoma

Gene

sex

Female

strain

C3H/HeEl

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99998 - Adult

genotype status

Wild-type

genetic manipulation

None

MA / Anatomical Site

MA 312 - lumbar vertebra

Designated Allele Name

Experimental Manipulation

Radiation

Further info

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Copyright

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Search PubMed:

PubMed number: 11893245