Pathbase: PB 196


Pathbase Image PB 196 submitted by Inst. of Biomedicine, Univ. of Helsinki on 2002-01-01
EMAP / Embryonic stage,
tissue or post-natal age:
99997 - Juvenile
Genotype Status:Homozygous
MPATH / Pathology:MPATH 127 - atrophy
Genetic Manipulation:Transgenic-Ectopic-overexpression
MA / Anatomical Site:MA 412 - seminiferous tubule
Designated Allele Name:
Experimental Manipulation:
Description:Disruption of spermatogenesis and accumulation of undifferentiated spermatogonia in GDNF overexpressing mice. Testicular morphology of GDNF-overexpressing mice is normal at birth. After 2 to 3 weeks, a chimeric histological pattern is observed. The tubular cross sections not only showed normal spermatogenesis but also displayed large cell clusters. Because these cells in the clusters did not show much nuclear heterochromatin and did express a spermatogonial marker, EE2, they could be morphologically classified as type A spermatogonia. The clusters gradually degenerated after puberty, resulting in tubular atrophy, and Sertoli cells phagocytosed the dead cells. At 10 weeks of age, only remnants of clusters were seen, but a rim of spermatogonia at the periphery of atrophic seminiferous tubules remained. No sperm was observed in seminiferous tubules or the epididymis.


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0005615 - extracellular space
Search AmiGO:GO ID: 0009653 - morphogenesis
Search AmiGO:GO ID: 0007399 - neurogenesis
Search AmiGO:GO ID: 0007422 - peripheral nervous system development
Search AmiGO:GO ID: 0030432 - peristalsis
Search AmiGO:GO ID: 0007179 - TGFbeta receptor signaling pathway
Search AmiGO:GO ID: 0005160 - transforming growth factor-beta receptor binding
Search AmiGO:GO ID: 0007169 - transmembrane receptor protein tyrosine kinase signaling pathway
Search AmiGO:GO ID: 0006916 - anti-apoptosis
Search AmiGO:GO ID: 0007422 - peripheral nervous system development
Search PubMed:PubMed number: 10688798
Search MGI@Jax:Gene: Gdnf
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!

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