Description

Disruption of spermatogenesis and accumulation of undifferentiated spermatogonia in GDNF overexpressing mice. Testicular morphology of GDNF-overexpressing mice is normal at birth. After 2 to 3 weeks, a chimeric histological pattern is observed. The tubular cross sections not only showed normal spermatogenesis but also displayed large cell clusters. Because these cells in the clusters did not show much nuclear heterochromatin and did express a spermatogonial marker, EE2, they could be morphologically classified as type A spermatogonia. The clusters gradually degenerated after puberty, resulting in tubular atrophy, and Sertoli cells phagocytosed the dead cells. At 10 weeks of age, only remnants of clusters were seen, but a rim of spermatogonia at the periphery of atrophic seminiferous tubules remained. No sperm was observed in seminiferous tubules or the epididymis.

MPATH / Pathology

MPATH 127 - atrophy

Gene

Gdnf

sex

Male

strain

FVB

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99997 - Juvenile

genotype status

Homozygous

genetic manipulation

Transgenic-Ectopic-overexpression

MA / Anatomical Site

MA 412 - seminiferous tubule

Designated Allele Name

Experimental Manipulation

Further info

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Copyright

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Gene Ontology

GO ID: 0005615 - extracellular space GO ID: 0009653 - morphogenesis GO ID: 0007399 - neurogenesis GO ID: 0007422 - peripheral nervous system development GO ID: 0030432 - peristalsis GO ID: 0007179 - TGFbeta receptor signaling pathway GO ID: 0005160 - transforming growth factor-beta receptor binding GO ID: 0007169 - transmembrane receptor protein tyrosine kinase signaling pathway GO ID: 0006916 - anti-apoptosis GO ID: 0007422 - peripheral nervous system development

Search PubMed:

PubMed number: 10688798

MGI:

Gene: Gdnf