Pathbase: PB 13354


Pathbase Image PB 13354 submitted by Zydus Cadila on 2003-08-04
Strain:BKS.Cg-m +/+ Leprdb
EMAP / Embryonic stage,
tissue or post-natal age:
99994 - Newborn
Genotype Status:Homozygous
MPATH / Pathology:MPATH 14 - process of degenerative change
Genetic Manipulation:Spontaneous-mutant
MA / Anatomical Site:MA 7 - limb
Designated Allele Name:diabetes; db
Experimental Manipulation:
Description:The two db/db male mice shown here , 15-17 weeks old (JAX # 000642) had all four distal limb joints swollen. There was no damage to any other bones. This phenotype has not been previously reported. Note that this strain may also contain the recessive misty (m) mutation. See JAX stock record for details. No histopathology available as yet for more precise diagnosis.


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0004888 - transmembrane receptor activity
Search AmiGO:GO ID: 0005515 - protein binding
Search AmiGO:GO ID: 0005615 - extracellular space
Search AmiGO:GO ID: 0005887 - integral to plasma membrane
Search AmiGO:GO ID: 0006112 - energy reserve metabolism
Search AmiGO:GO ID: 0007165 - signal transduction
Search AmiGO:GO ID: 0016021 - integral to membrane
Search AmiGO:GO ID: 0019222 - regulation of metabolism
Search PubMed:PubMed number: 8608603
Search MGI@Jax:Gene: Lepr
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!

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