Description

The two db/db male mice shown here , 15-17 weeks old (JAX # 000642) had all four distal limb joints swollen. There was no damage to any other bones. This phenotype has not been previously reported. Note that this strain may also contain the recessive misty (m) mutation. See JAX stock record for details. No histopathology available as yet for more precise diagnosis.

MPATH / Pathology

MPATH 14 - process of degenerative change

Gene

Lepr

sex

Male

strain

BKS.Cg-m +/+ Lepr^db

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99994 - Newborn

genotype status

Homozygous

genetic manipulation

Spontaneous-mutant

MA / Anatomical Site

MA 7 - limb

Designated Allele Name

diabetes; db

Experimental Manipulation

Further info

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Copyright

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Gene Ontology

GO ID: 0004888 - transmembrane receptor activity GO ID: 0005515 - protein binding GO ID: 0005615 - extracellular space GO ID: 0005887 - integral to plasma membrane GO ID: 0006112 - energy reserve metabolism GO ID: 0007165 - signal transduction GO ID: 0016021 - integral to membrane GO ID: 0019222 - regulation of metabolism

Search PubMed:

PubMed number: 8608603

MGI:

Gene: Lepr