Skinbase

The fuzzy mutation arose spontaneously in 1945 in the CFW stock of Dr. Canochan at the Carworth Farms. An allele (fz2J) arose spontaneously in 1979 in the AKR/J strain at The Jackson Laboratory. Additional alleles have been found either arising spontaneously or in ENU mutagenesis programs. The gene was originally mapped to Chr. 1, 5 cM from the centromere. The mutation appears to have been identified and this should be published in the near future.

Mutant mice can be identified as early as 6 days of age by the presence of thin and wavey vibrissae and an uneven hair coat over the body. Plucked hairs are wavy with many areas that are flattened to form constrictions at bends. Early studies found abnormalities in the dermal papilla within anagen hair follicles and scattered dilated piliary canals filled with hair fiber debris.

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Major MH; Hawkins MS, fz<fy> - frowzy, Mouse News Lett 1958;19():37

Monroe; Major MH; Hawkins MS, Hair abnormality (fz), Mouse News Lett 1958;19():37

Parsons PA, A balanced four-point linkage experiment for linkage group XIII of the house mouse, Heredity 1958;12():77-95

Russell LB, Frowzy, fz, Mouse News Lett 1960;22():49-50

Searle AG, The genetics and morphology of two 'luxoid' mutants in the house mouse, Genet Res 1964;5():171-197

Mann SJ, The hair of the fuzzy mouse., J Hered 1964 May-Jun;55():121-123

Kelton DE, [Three point test of ln, fz and dt], Mouse News Lett 1965;32():60

Hollander WF, fz, Mouse News Lett 1966;35():30

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Roderick TH, Location of dipeptidase-1 (Dip-1), Mouse News Lett 1971;44():30

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Trigg MJ, Hair growth in mouse mutants affecting coat texture., J Zool 1972;168():165-198

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Mayer TC; Mittelberger JA; Green MC, The site of action of the fuzzy locus (fz) in the mouse, as determined by dermal-epidermal recombinations., J Embryol Exp Morphol 1974 Dec;32(3):707-13

Davisson MT; Roderick TH, [Linkage: fuzzy, leaden, Chr 1.], Mouse News Lett 1975;52():38

Taylor BA; O'Brien AD, Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium., Infect Immun 1982 Jun;36(3):1257-60

Borodin PM; Gorlov IP; Ladygina TYu, Double insertion of homogeneously staining regions in chromosome 1 of wild Mus musculus musculus: effects on chromosome pairing and recombination., J Hered 1990 Mar-Apr;81(2):91-5

Berdaliev AS, Koniukhov BV., The site of the action of the angora-Y gene and its interaction with the fuzzy-Y gene in the mouse, Izv Akad Nauk SSSR Biol. 1991 May-Jun;(3):352-60. Russian.

Davisson MT; Akeson EC, Recombination suppression by heterozygous Robertsonian chromosomes in the mouse., Genetics 1993 Mar;133(3):649-67

Evans EP; Beechey CV; Burtenshaw MD; Searle AG, T(In1;5)44H, a complex mouse chromosomal rearrangement with a phenotypic effect., Cytogenet Cell Genet 1993;63(1):66-72

Everett CA; Glenister PH; Taylor DM; Lyon MF; Kratochvilova-Loester J; Favor J, Mapping of six dominant cataract genes in the mouse., Genomics 1994 Apr;20(3):429-34

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Sundberg JP, The Fuzzy (fz) Mutation, Chromosome 1, In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. Sundberg, JP (ed.), CRC Press, Boca Raton, FL, pp 279-283, 1994.

Christner PJ; Siracusa LD; Hawkins DF; McGrath R; Betz JK; Ball ST ; Jimenez SA ; Peters J, A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases., Mamm Genome 1996 Aug;7(8):610-2

Lyon MF; Quinney R; Glenister PH; Kerscher S; Guillot P; Boyd Y, Doublefoot: a new mouse mutant affecting development of limbs and head., Genet Res 1996 Dec;68(3):221-31

Cirlan MV, A new mutation at the fuzzy (fz) locus, MGI Direct Data Submission 2004;():