Depilated is an autosomal recessive mutation that was mapped to Chromosome 4. It arose spontaneously in 1966 at The Jackson Laboratory. Mutant mice can be identified as early as 1 week of age when hairs first emerge from follicles by mice having an abnormally thin, short first hair coat. Some mice will be nearly completely hairless by 3 weeks of age but if hair is present it appears to be matted and greasy. Plucked hairs have irregular septae or complete interruption of the normal septal pattern. The melanocytes had normal morphologic features without melanosome clumping. In histologic sections there were various degrees of follicular dystrophy. Detailed studies on anatomic changes have yet to be done.
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