PB 24159
Description
Cribriform epididymal hyperplasia was initially described as an accidental finding in human orchidectomy specimens. Recently, this condition was also described in mice, homozygous for a targeted mutation in p53.
MPATH / Pathology
MPATH 587 - Cribriform epididymal hyperplasia
Gene
Trp53
sex
Male
strain
129/Sv;FVB/N
organism
Mouse
EMAP / Embryonic stage, tissue or post-natal age:
99998 - Adult
genotype status
Homozygous
genetic manipulation
Gene-knockout-deletion
MA / Anatomical Site
MA 1735 - epididymal duct
Designated Allele Name
Experimental Manipulation
Further info
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Copyright
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Gene Ontology
GO ID: 0000060 - protein-nucleus import, translocation GO ID: 0003677 - DNA binding GO ID: 0003700 - transcription factor activity GO ID: 0005515 - protein binding GO ID: 0005634 - nucleus GO ID: 0005737 - cytoplasm GO ID: 0005829 - cytosol GO ID: 0006350 - transcription GO ID: 0006355 - regulation of transcription, DNA-dependent GO ID: 0006915 - apoptosis GO ID: 0008151 - cell growth and/or maintenance GO ID: 0030330 - DNA damage response, signal transduction by p53 class mediator GO ID: 0045182 - translation regulator activity