Description

Ectopic crypts in the colon in a p53 null mouse expressing Igf2 from a cytokeratin promoter.

MPATH / Pathology

MPATH 55 - developmental and structural abnormality
MPATH 86 - organ specific developmental defect

Gene

Trp53
Igf2

sex

Unknown

strain

CBA;C57BL/6

organism

Mouse

EMAP / Embryonic stage, tissue or post-natal age:

99998 - Adult

genotype status

Homozygous

genetic manipulation

Gene-knockout-deletion
Transgenic-Ectopic-overexpression

MA / Anatomical Site

MA 1527 - hindgut

Designated Allele Name

Experimental Manipulation

Further info

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Copyright

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Gene Ontology

GO ID: 0001501 - skeletal development GO ID: 0005159 - insulin-like growth factor receptor binding GO ID: 0005615 - extracellular space GO ID: 0006349 - imprinting GO ID: 0007150 - growth pattern GO ID: 0007275 - development GO ID: 0008286 - insulin receptor signaling pathway GO ID: 0009887 - organogenesis GO ID: 0009887 - organogenesis

MGI:

Gene: Igf2

MGI:

Gene: Trp53