Pathbase: PB 24079


Pathbase Image PB 24079 submitted by University of Cambridge on 2003-11-01
Strain:C57BL/6 CRL
EMAP / Embryonic stage,
tissue or post-natal age:
99994 - Newborn
Genotype Status:Wild-type
MPATH / Pathology:MPATH 458 - normal
Genetic Manipulation:None
MA / Anatomical Site:MA 1600 - lower jaw incisor
Designated Allele Name:
Experimental Manipulation:
Description:Partially erupted second molar. While crown is fully developed root formation is still ongoing. Due to decalcification during preparation the enamel is not seen, the space filled by enamel contains some non-degraded enamel matrix particularly seen in the distal portion near the cervix. The space defined by enamel is lined by reduced enamel epithelium, ie. ameloblasts. Outside this, stellate reticulum is present and limited by the outer enamel epithelium.

In the coronal portion, dentine formation is nearly complete and towards the pulpal cavity the mineralised dentine is lined by a thin layer of unmineralised pre-dentine. Bordering the pre-dentine, and slightly obliquely sectioned, odontoblasts are seen.

In the apical part the apices are still wide open and root formation is still ongoing. The apical part is delimited by Hertwig`s root sheath.

To the left in the image formation of alveolar bone is seen while in the space between the alveolar bone and the forming root is the developing periondotal ligament. At this stage the ligament is immature and densely populated by fibroblasts synthesising the collagen scaffold that provides connection between the root surface and the alveolar bone.


Further Information
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