Pathbase

Pathbase: PB 24076

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Pathbase Image PB 24076 submitted by Pathbase on 2003-10-31
Sex:Male
Gene:Eda
ectodysplasin-A
Strain:B6CBACa Aw-J/A-EdaTa/Y
Organism:Mouse
EMAP / Embryonic stage,
tissue or post-natal age:
Genotype Status:Hemizygous
MPATH / Pathology:MPATH 58 - aplasia
Genetic Manipulation:Spontaneous-mutant
MA / Anatomical Site:MA 694 - limb skin
Designated Allele Name:Ta
tabby
Experimental Manipulation:
Description:Footpad X-linked ectodermal dysplasia. The image shows aplasia of eccrine glands due to mutation of the ectodysplasin gene (Tabby).


Magnification:10
Stain:H&E


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0005164 - tumor necrosis factor receptor binding
Search AmiGO:GO ID: 0005789 - endoplasmic reticulum membrane
Search AmiGO:GO ID: 0005887 - integral to plasma membrane
Search AmiGO:GO ID: 0006955 - immune response
Search AmiGO:GO ID: 0007160 - cell-matrix adhesion
Search AmiGO:GO ID: 0007275 - development
Search AmiGO:GO ID: 0007431 - salivary gland development
Search AmiGO:GO ID: 0016020 - membrane
Search AmiGO:GO ID: 0016021 - integral to membrane
Search AmiGO:GO ID: 0030154 - cell differentiation
Search AmiGO:GO ID: 0042346 - positive regulation of NF-kappaB protein-nucleus import
Search AmiGO:GO ID: 0045177 - apical part of cell
Search PubMed:PubMed number: 12692542
Search MGI@Jax:Gene: ectodysplasin-A
Search MGI@Jax:Gene: Eda
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!


Copyright
This image remains the property of the originating Institution and should not be modified, reproduced or disseminated without the express permission of the submitter.




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