PB 24069
Description
Composite lymphoma - thymic lymphoblastic and marginal zone lymphomas in spleen
MPATH / Pathology
MPATH 521 - splenic marginal zone lymphoma
MPATH 537 - precursor T-cell lymphoblastic lymphoma/leukaemia
Gene
Trp53
transformation related protein 53
sex
Unknown
strain
B6;129S2-Trp53tm1Tyj
organism
Mouse
EMAP / Embryonic stage, tissue or post-natal age:
genotype status
Wild-type
genetic manipulation
Gene-knockout-deletion
MA / Anatomical Site
MA 141 - spleen
Designated Allele Name
targeted mutation 1, Tyler Jacks
tm1Tyj
Experimental Manipulation
Further info
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Copyright
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Gene Ontology
GO ID: 0000060 - protein-nucleus import, translocation GO ID: 0003677 - DNA binding GO ID: 0003700 - transcription factor activity GO ID: 0005515 - protein binding GO ID: 0005634 - nucleus GO ID: 0005737 - cytoplasm GO ID: 0005829 - cytosol GO ID: 0006350 - transcription GO ID: 0006355 - regulation of transcription, DNA-dependent GO ID: 0006915 - apoptosis GO ID: 0008151 - cell growth and/or maintenance GO ID: 0030330 - DNA damage response, signal transduction by p53 class mediator GO ID: 0045182 - translation regulator activity
MGI:
Gene: transformation related protein 53