PB 153
Description
Cystic fibrosis in mutant colon in Cftrtm2Cam mice carrying the most common mutation in cystic fibrosis (CF), delta F508, within the cystic fibrosis (Cftr) gene. Crypt distention and mucus hyperaccumulation noted
MPATH / Pathology
MPATH 62 - cyst
MPATH 547 - mucous secretions
Gene
Cftr
sex
Female
strain
129-Cftrtm2Cam;C57BL/6
organism
Mouse
EMAP / Embryonic stage, tissue or post-natal age:
99998 - Adult
genotype status
Homozygous
genetic manipulation
Gene-knockout-mutation
MA / Anatomical Site
MA 335 - colon
Designated Allele Name
Experimental Manipulation
Further info
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Copyright
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Gene Ontology
GO ID: 0005224 - ATP-binding and phosphorylation-dependent chloride channel activity GO ID: 0005254 - chloride channel activity GO ID: 0005886 - plasma membrane GO ID: 0005887 - integral to plasma membrane GO ID: 0006832 - small molecule transport GO ID: 0007125 - invasive growth GO ID: 0007585 - respiratory gaseous exchange