Pathbase

Pathbase: PB 153

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Pathbase Image PB 153 submitted by University of Cambridge on 2001-09-25
Sex:Female
Gene:Cftr
Strain:129-Cftrtm2Cam;C57BL/6
Organism:Mouse
EMAP / Embryonic stage,
tissue or post-natal age:
99998 - Adult
Genotype Status:Homozygous
MPATH / Pathology:MPATH 62 - cyst
MPATH 547 - mucous secretions
Genetic Manipulation:Gene-knockout-mutation
MA / Anatomical Site:MA 335 - colon
Designated Allele Name:
Experimental Manipulation:
Description:Cystic fibrosis in mutant colon in Cftrtm2Cam mice carrying the most common mutation in cystic fibrosis (CF), delta F508, within the cystic fibrosis (Cftr) gene. Crypt distention and mucus hyperaccumulation noted


Magnification:
Stain:H&E


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0005224 - ATP-binding and phosphorylation-dependent chloride channel activity
Search AmiGO:GO ID: 0005254 - chloride channel activity
Search AmiGO:GO ID: 0005886 - plasma membrane
Search AmiGO:GO ID: 0005887 - integral to plasma membrane
Search AmiGO:GO ID: 0006832 - small molecule transport
Search AmiGO:GO ID: 0007125 - invasive growth
Search AmiGO:GO ID: 0007585 - respiratory gaseous exchange
Search the Mouse Phenome Database:MPD number: 2476
Search PubMed:PubMed number: 7545494
Search MGI@Jax:Gene: Cftr
Images of the same study:Study number: 3
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!


Copyright
This image remains the property of the originating Institution and should not be modified, reproduced or disseminated without the express permission of the submitter.




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