Pathbase

Pathbase: PB 1235

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Pathbase Image PB 1235 submitted by University of Cambridge on 2002-06-11
Sex:Male
Gene:Ptch
Strain:(129SV-Ptchtm1Zim;C57BL/6); CD1
Organism:Mouse
EMAP / Embryonic stage,
tissue or post-natal age:
99998 - Adult
Genotype Status:Heterozygous
MPATH / Pathology:MPATH 406 - dermatofibrosarcoma
Genetic Manipulation:Gene-knockout-deletion
MA / Anatomical Site:MA 517 - trunk skin
Designated Allele Name:Ptch
Patched
Experimental Manipulation:Radiation
Description:Multiform fibrosarcomas in male mouse with targeted deletion of Ptch after irradiation with 3 Gy of X-rays.


Magnification:250
Stain:Masson`s Trichrome


Further Information
Gene Ontology Terms associated with the genes involved in this lesion may be searched on AMIGO by clicking on each GO ID number below:
Search AmiGO:GO ID: 0005887 - integral to plasma membrane
Search AmiGO:GO ID: 0007226 - regulation of smoothened receptor by patched
Search AmiGO:GO ID: 0008158 - patched receptor activity
Search AmiGO:GO ID: 0016021 - integral to membrane
Search AmiGO:GO ID: 0030326 - limb morphogenesis
Search AmiGO:GO ID: 0040015 - negative regulation of body size
Search the Mouse Phenome Database:MPD number: 5525
Search PubMed:PubMed number: 12386820
Search MGI@Jax:Gene: Ptch
Images of the same study:Study number: 4
NOTE: Not all terms are currently shared between Pathbase and the above databases, some searches may not produce returns, in which case users should use synonyms or more inclusive text terms to search manually!


Copyright
This image remains the property of the originating Institution and should not be modified, reproduced or disseminated without the express permission of the submitter.




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